Details

Autor(en) / Beteiligte

• Feng, Shuo
• Phillips, Daniel J
• White, Thomas
• Sayal, Homesh
• Aley, Parvinder K
• Bibi, Sagida
• Dold, Christina
• Fuskova, Michelle
• Gilbert, Sarah C
• Hirsch, Ian
• Humphries, Holly E
• Jepson, Brett
• Kelly, Elizabeth J
• Plested, Emma
• Shoemaker, Kathryn
• Thomas, Kelly M
• Vekemans, Johan
• Villafana, Tonya L
• Lambe, Teresa
• Pollard, Andrew J
• Voysey, Merryn

Titel

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Ist Teil von

• Nature medicine, 2021-11, Vol.27 (11), p.2032-2040

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. Data from a randomized efficacy trial of the ChAdOx1 nCoV-19 (AZD1222) vaccine in the United Kingdom was analyzed to determine the antibody levels associated with protection against SARS-CoV-2. Binding and neutralizing antibodies at 28 days after the second dose were measured in infected and noninfected vaccine recipients. Higher levels of all immune markers were correlated with a reduced risk of symptomatic infection. A vaccine efficacy of 80% against symptomatic infection with majority Alpha (B.1.1.7) variant of SARS-CoV-2 was achieved with 264 (95% CI: 108, 806) binding antibody units (BAU)/ml: and 506 (95% CI: 135, not computed (beyond data range) (NC)) BAU/ml for anti-spike and anti-RBD antibodies, and 26 (95% CI: NC, NC) international unit (IU)/ml and 247 (95% CI: 101, NC) normalized neutralization titers (NF ) for pseudovirus and live-virus neutralization, respectively. Immune markers were not correlated with asymptomatic infections at the 5% significance level. These data can be used to bridge to new populations using validated assays, and allow extrapolation of efficacy estimates to new COVID-19 vaccines.