Details

Autor(en) / Beteiligte

• Luporini, Rafael Luís
• Pott-Junior, Henrique
• Di Medeiros Leal, Maria Carolina B.
• Castro, Alex
• Ferreira, Antonio Gilberto
• Cominetti, Marcia Regina
• de Freitas Anibal, Fernanda

Titel

Phenylalanine and COVID-19: Tracking disease severity markers

Ist Teil von

• International immunopharmacology, 2021-12, Vol.101 (Pt A), p.108313-108313, Article 108313

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •There is a need to investigate alternative predictors of COVID-19 severity.•Current most used markers for COVID-19 severity are not specific.•Phenylalanine and tyrosine serum levels are higher in moderate/severe COVID-19.•Phenylalanine is independently and positively associated with disease severity. Although there are several severity predictors for COVID-19, none are specific. Serum levels of phenylalanine were recently associated with increased inflammation, higher SOFA scores, ICU admission, and mortality rates among non-COVID-19 patients. Here, we investigated the relationship between phenylalanine and inflammatory markers in adults with COVID-19. We assessed adults with COVID-19 at hospital admission for clinical and laboratory data. Nuclear magnetic resonance spectroscopy measured serum levels of phenylalanine and other amino acids of its metabolomic pathway. Flow Cytometry measured serum levels of IL-2, IL-4, IL-6, Il-10, TNF-α, and IFN-γ. Linear regression models adjusted for potential confounders assessed the relationship between serum levels of phenylalanine and inflammatory cytokines. Phenylalanine and tyrosine were significantly lower in mild disease as compared to moderate and severe groups. Linear regression models showed that phenylalanine is independently and positively associated with disease severity regardless of the cytokine analyzed and after adjustment for potential confounders. In addition, mild cases showed consistently lower serum phenylalanine levels within the first ten days from disease onset to hospital admission. Phenylalanine is a marker of disease severity. This association is independent of the time between the onset of symptoms and the magnitude of the inflammatory state.