Proceedings of the National Academy of Sciences - PNAS, 2021-10, Vol.118 (42), p.1-8
2021
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Details
- Autor(en) / Beteiligte
- Titel
- Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2021-10, Vol.118 (42), p.1-8
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2021
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide (SNIO) particles that exhibit superparamagnetic properties in conjunction with hydrodynamic diameters comparable to small, highly diffusible imaging agents. These particles efficiently brighten the signal in T₁-weighted MRI, producing per-molecule longitudinal relaxation enhancements over 10 times greater than conventional gadolinium-based contrast agents. We show that SNIOs permeate biological tissue effectively following injection into brain parenchyma or cerebrospinal fluid. We also demonstrate that SNIOs readily enter the brain following ultrasound-induced blood–brain barrier disruption, emulating the performance of a gadolinium agent and providing a basis for future biomedical applications. These results thus demonstrate a platform for MRI probe development that combines advantages of smallmolecule imaging agents with the potency of nanoscale materials.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.2102340118Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8545496
- Format
- –
- Schlagworte
- Animals, Biological effects, Biological Sciences, Biomedical materials, Blood-Brain Barrier, brain, Cerebrospinal fluid, Contrast agents, Contrast media, Contrast Media - administration & dosage, Contrast Media - pharmacokinetics, Gadolinium, INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY, iron oxide nanoparticle, Iron oxides, Magnetic Iron Oxide Nanoparticles - administration & dosage, Magnetic Iron Oxide Nanoparticles - chemistry, Magnetic permeability, Magnetic resonance imaging, Magnetic Resonance Imaging - methods, Medical imaging, molecular imaging, Nanoparticles, Neuroimaging, Parenchyma, Particle Size, Permeability, Physical Sciences, Rats, Tissues