Details

Autor(en) / Beteiligte

• Demonbreun, Alexis R
• Sancilio, Amelia
• Velez, Matt E
• Ryan, Daniel T
• Pesce, Lorenzo
• Saber, Rana
• Vaught, Lauren A
• Reiser, Nina L
• Hsieh, Ryan R
• D’Aquila, Richard T
• Mustanski, Brian
• McDade, Thomas W
• McNally, Elizabeth M

Titel

COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men

Ist Teil von

• The Journal of infectious diseases, 2021-09, Vol.224 (5), p.793-797

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2021

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.