Details

Autor(en) / Beteiligte

• Zhu, Qiyun
• Hou, Qiangchuan
• Huang, Shi
• Ou, Qianying
• Huo, Dongxue
• Vázquez-Baeza, Yoshiki
• Cen, Chaoping
• Cantu, Victor
• Estaki, Mehrbod
• Chang, Haibo
• Belda-Ferre, Pedro
• Kim, Ho-Cheol
• Chen, Kaining
• Knight, Rob
• Zhang, Jiachao

Titel

Compositional and genetic alterations in Graves’ disease gut microbiome reveal specific diagnostic biomarkers

Ist Teil von

• The ISME Journal, 2021-11, Vol.15 (11), p.3399-3411

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Graves’ Disease is the most common organ-specific autoimmune disease and has been linked in small pilot studies to taxonomic markers within the gut microbiome. Important limitations of this work include small sample sizes and low-resolution taxonomic markers. Accordingly, we studied 162 gut microbiomes of mild and severe Graves’ disease (GD) patients and healthy controls. Taxonomic and functional analyses based on metagenome-assembled genomes (MAGs) and MAG-annotated genes, together with predicted metabolic functions and metabolite profiles, revealed a well-defined network of MAGs, genes and clinical indexes separating healthy from GD subjects. A supervised classification model identified a combination of biomarkers including microbial species, MAGs, genes and SNPs, with predictive power superior to models from any single biomarker type (AUC = 0.98). Global, cross-disease multi-cohort analysis of gut microbiomes revealed high specificity of these GD biomarkers, notably discriminating against Parkinson’s Disease, and suggesting that non-invasive stool-based diagnostics will be useful for these diseases.