Details

Autor(en) / Beteiligte

• Yoo, Woongjae
• Zieba, Jacob K
• Foegeding, Nora J
• Torres, Teresa P
• Shelton, Catherine D
• Shealy, Nicolas G
• Byndloss, Austin J
• Cevallos, Stephanie A
• Gertz, Erik
• Tiffany, Connor R
• Thomas, Julia D
• Litvak, Yael
• Nguyen, Henry
• Olsan, Erin E
• Bennett, Brian J
• Rathmell, Jeffrey C
• Major, Amy S
• Bäumler, Andreas J
• Byndloss, Mariana X

Titel

High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N -oxide

Ist Teil von

• Science (American Association for the Advancement of Science), 2021-08, Vol.373 (6556), p.813-818

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to a high-fat diet escalates choline catabolism by altering intestinal epithelial physiology. A high-fat diet impaired the bioenergetics of mitochondria in the colonic epithelium to increase the luminal bioavailability of oxygen and nitrate, thereby intensifying respiration-dependent choline catabolism of In turn, choline catabolism increased levels of circulating trimethlamine -oxide, which is a potentially harmful metabolite generated by gut microbiota.