Details

Autor(en) / Beteiligte

• Jafarpour, Roghayeh
• Pashangzadeh, Salar
• Dowran, Razieh

Titel

Host factors: Implications in immunopathogenesis of COVID-19

Ist Teil von

• Pathology, research and practice, 2021-12, Vol.228, p.153647-153647, Article 153647

Ort / Verlag

Germany: Elsevier GmbH

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is more serious in people with underlying diseases, but the cause of healthy people with progressive disease is largely unknown. Host genetic factors such as ACE2 variants, IFITM-3, HLA, TMRSS2, and furin polymorphisms appear to be one of the agents involved in the progression of the COVID-19 and outcome of the disease. This review discusses the general characteristics of SARS-CoV-2, including viral features, receptors, cell entry, clinical findings, and the main human genetic factors that may contribute to the pathogenesis of COVID-19 and get the patients’ situation more complex. Further knowledge in this context may help to find a way to prevent and treat this viral pneumonia.