Nature medicine, 2020-07, Vol.26 (7), p.1044-1047
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes
- Ist Teil von
- Nature medicine, 2020-07, Vol.26 (7), p.1044-1047
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2020
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show that DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately discriminate common primary intracranial tumors that share cell-of-origin lineages and can be challenging to distinguish using standard-of-care imaging.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956eISSN: 1546-170XDOI: 10.1038/s41591-020-0932-2Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8500275
- Format
- –
- Schlagworte
- Biomarkers, Tumor - blood, Brain cancer, Brain Neoplasms - blood, Brain Neoplasms - diagnosis, Brain Neoplasms - genetics, Brain Neoplasms - pathology, Brain tumors, Cancer, Cell-Free Nucleic Acids - blood, CpG Islands - genetics, Deoxyribonucleic acid, Diagnosis, Diagnostic systems, DNA, DNA methylation, DNA Methylation - genetics, DNA sequencing, DNA, Neoplasm - blood, Epigenome - genetics, Female, Gene Expression Regulation, Neoplastic - genetics, Genetic aspects, Health aspects, Humans, Male, Methylation, Neuroimaging, Oncology, Experimental, Surgery, Tumors