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Cellular anatomy of the mouse primary motor cortex
Nature (London), 2021-10, Vol.598 (7879), p.159-166
2021

Details

Autor(en) / Beteiligte
Titel
Cellular anatomy of the mouse primary motor cortex
Ist Teil von
  • Nature (London), 2021-10, Vol.598 (7879), p.159-166
Ort / Verlag
England: Nature Publishing Group
Erscheinungsjahr
2021
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted . Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input-output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.
Sprache
Englisch
Identifikatoren
ISSN: 0028-0836
eISSN: 1476-4687
DOI: 10.1038/s41586-021-03970-w
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8494646
Format
–
Schlagworte
Anatomy, Animals, Atlases as Topic, Bioinformatics, Brain, Brain architecture, Cellular structure, Circuits, Collaboration, Cortex (motor), Datasets, Female, GABAergic Neurons - cytology, GABAergic Neurons - metabolism, Gene expression, Glutamates - metabolism, Image reconstruction, Labeling, Labelling, Laboratories, Male, Medical imaging, Mice, Mice, Inbred C57BL, Motor Cortex - anatomy & histology, Motor Cortex - cytology, Motor task performance, Neuroimaging, Neurons, Neurons - classification, Neurons - cytology, Neurons - metabolism, Organ Specificity, Sequence Analysis, RNA, Single-Cell Analysis, Spinal cord, Tropical diseases, Wiring

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