Details

Autor(en) / Beteiligte

• Thaler, Franziska S
• Zimmermann, Luise
• Kammermeier, Stefan
• Strippel, Christine
• Ringelstein, Marius
• Kraft, Andrea
• Sühs, Kurt-Wolfram
• Wickel, Jonathan
• Geis, Christian
• Markewitz, Robert
• Urbanek, Christian
• Sommer, Claudia
• Doppler, Kathrin
• Penner, Loana
• Lewerenz, Jan
• Rößling, Rosa
• Finke, Carsten
• Prüss, Harald
• Melzer, Nico
• Wandinger, Klaus-Peter
• Leypoldt, Frank
• Kümpfel, Tania

Titel

Rituximab Treatment and Long-term Outcome of Patients With Autoimmune Encephalitis: Real-world Evidence From the GENERATE Registry

Ist Teil von

• Neurology : neuroimmunology & neuroinflammation, 2021-11, Vol.8 (6)

Ort / Verlag

United States: Lippincott Williams & Wilkins

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine the real-world use of rituximab in autoimmune encephalitis (AE) and to correlate rituximab treatment with the long-term outcome. Patients with NMDA receptor (NMDAR)-AE, leucine-rich glioma-inactivated-1 (LGI1)- AE, contactin-associated protein-like-2 (CASPR2)-AE, or glutamic acid decarboxylase 65 (GAD65) disease from the GErman Network for Research on AuToimmune Encephalitis who had received at least 1 rituximab dose and a control cohort of non-rituximab-treated patients were analyzed retrospectively. Of the 358 patients, 163 (46%) received rituximab (NMDAR-AE: 57%, CASPR2-AE: 44%, LGI1-AE: 43%, and GAD65 disease: 37%). Rituximab treatment was initiated significantly earlier in NMDAR- and LGI1-AE (median: 54 and 155 days from disease onset) compared with CASPR2-AE or GAD65 disease (median: 632 and 1,209 days). Modified Rankin Scale (mRS) scores improved significantly in patients with NMDAR-AE, both with and without rituximab treatment. Although being more severely affected at baseline, rituximab-treated patients with NMDAR-AE more frequently reached independent living (mRS score ≤2) (94% vs 88%). In LGI1-AE, rituximab-treated and nontreated patients improved, whereas in CASPR2-AE, only rituximab-treated patients improved significantly. No improvement was observed in patients with GAD65 disease. A significant reduction of the relapse rate was observed in rituximab-treated patients (5% vs 13%). Detection of NMDAR antibodies was significantly associated with mRS score improvement. A favorable outcome was also observed with early treatment initiation. We provide real-world data on immunosuppressive treatments with a focus on rituximab treatment for patients with AE in Germany. We suggest that early and short-term rituximab therapy might be an effective and safe treatment option in most patients with NMDAR-, LGI1-, and CASPR2-AE. This study provides Class IV evidence that rituximab is an effective treatment for some types of AE.