Arthritis research, 2002-01, Vol.4 (2), p.139-144, Article 139
2002
Details
- Autor(en) / Beteiligte
- Titel
- Expression of interleukin-18 receptor in fibroblast-like synoviocytes
- Ist Teil von
- Arthritis research, 2002-01, Vol.4 (2), p.139-144, Article 139
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2002
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R alpha-chain and beta-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1465-9905, 1478-6362, 1478-6354eISSN: 1465-9913, 1478-6362DOI: 10.1186/ar390Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_83844
- Format
- –
- Schlagworte
- Analysis, Arthritis, Rheumatoid - immunology, Arthritis, Rheumatoid - metabolism, Care and treatment, Cell Division - drug effects, Cells, Cultured, Cellular signal transduction, Collagenases - metabolism, Culture Media, Conditioned - metabolism, Diagnosis, Dinoprostone - metabolism, Fibroblasts, Fibroblasts - drug effects, Fibroblasts - metabolism, Fibroblasts - pathology, Health aspects, Humans, Intercellular Adhesion Molecule-1 - metabolism, Interleukin-18 - metabolism, Interleukin-18 - pharmacology, Interleukin-18 Receptor alpha Subunit, Interleukin-6 - metabolism, Interleukin-8 - metabolism, Interleukins, Matrix Metalloproteinase 3 - metabolism, Nitric Oxide - metabolism, Receptors, Interleukin - genetics, Receptors, Interleukin - metabolism, Receptors, Interleukin-18, Rheumatoid arthritis, RNA, Messenger - metabolism, Signal Transduction, Synovial Membrane - drug effects, Synovial Membrane - metabolism, Synovial Membrane - pathology, U937 Cells - drug effects, U937 Cells - metabolism, U937 Cells - pathology, Vascular Cell Adhesion Molecule-1 - metabolism