Details

Autor(en) / Beteiligte

• Stankov, Metodi V
• Cossmann, Anne
• Bonifacius, Agnes
• Dopfer-Jablonka, Alexandra
• Ramos, Gema Morillas
• Gödecke, Nina
• Scharff, Anna Zychlinsky
• Happle, Christine
• Boeck, Anna-Lena
• Tran, Anh Thu
• Pink, Isabell
• Hoeper, Marius M
• Blasczyk, Rainer
• Winkler, Martin S
• Nehlmeier, Inga
• Kempf, Amy
• Hofmann-Winkler, Heike
• Hoffmann, Markus
• Eiz-Vesper, Britta
• Pöhlmann, Stefan
• Behrens, Georg M N

Titel

Humoral and Cellular Immune Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants and Human Coronaviruses After Single BNT162b2 Vaccination

Ist Teil von

• Clinical infectious diseases, 2021-12, Vol.73 (11), p.2000-2008

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Vaccine-induced neutralizing antibodies are key in combating the coronavirus disease 2019 (COVID-19) pandemic. However, delays of boost immunization due to limited availability of vaccines may leave individuals vulnerable to infection and prolonged or severe disease courses. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC)-B.1.1.7 (United Kingdom), B.1.351 (South Africa), and P.1 (Brazil)-may exacerbate this issue, as the latter two are able to evade control by antibodies. We assessed humoral and T-cell responses against SARS-CoV-2 wild-type (WT), VOC, and endemic human coronaviruses (hCoVs) that were induced after single and double vaccination with BNT162b2. Despite readily detectable immunoglobulin G (IgG) against the receptor-binding domain of the SARS-CoV-2 S protein at day 14 after a single vaccination, inhibition of SARS-CoV-2 S-driven host cell entry was weak and particularly low for the B.1.351 variant. Frequencies of SARS-CoV-2 WT and VOC-specific T cells were low in many vaccinees after application of a single dose and influenced by immunity against endemic hCoV. The second vaccination significantly boosted T-cell frequencies reactive for WT and B.1.1.7 and B.1.351 variants. These results call into question whether neutralizing antibodies significantly contribute to protection against COVID-19 upon single vaccination and suggest that cellular immunity is central for the early defenses against COVID-19.