Details

Autor(en) / Beteiligte

• Zhang, Shangzhe
• Liu, Wenyu
• Liu, Xinfeng
• Du, Xin
• Zhang, Ke
• Zhang, Yang
• Song, Yongwu
• Zi, Yunnan
• Qiu, Qiang
• Lenstra, Johannes A
• Liu, Jianquan
• Yang, Guang

Titel

Structural Variants Selected during Yak Domestication Inferred from Long-Read Whole-Genome Sequencing

Ist Teil von

• Molecular biology and evolution, 2021-09, Vol.38 (9), p.3676-3680

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Structural variants (SVs) represent an important genetic resource for both natural and artificial selection. Here we present a chromosome-scale reference genome for domestic yak (Bos grunniens) that has longer contigs and scaffolds (N50 44.72 and 114.39 Mb, respectively) than reported for any other ruminant genome. We further obtained long-read resequencing data for 6 wild and 23 domestic yaks and constructed a genetic SV map of 372,220 SVs that covers the geographic range of the yaks. The majority of the SVs contains repetitive sequences and several are in or near genes. By comparing SVs in domestic and wild yaks, we identified genes that are predominantly related to the nervous system, behavior, immunity, and reproduction and may have been targeted by artificial selection during yak domestication. These findings provide new insights in the domestication of animals living at high altitude and highlight the importance of SVs in animal domestication.