Details

Autor(en) / Beteiligte

• Jackson, Ben
• Boni, Maciej F.
• Bull, Matthew J.
• Colleran, Amy
• Colquhoun, Rachel M.
• Darby, Alistair C.
• Haldenby, Sam
• Hill, Verity
• Lucaci, Anita
• McCrone, John T.
• Nicholls, Samuel M.
• O’Toole, Áine
• Pacchiarini, Nicole
• Poplawski, Radoslaw
• Scher, Emily
• Todd, Flora
• Webster, Hermione J.
• Whitehead, Mark
• Wierzbicki, Claudia
• Loman, Nicholas J.
• Connor, Thomas R.
• Robertson, David L.
• Pybus, Oliver G.
• Rambaut, Andrew

Titel

Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic

Ist Teil von

• Cell, 2021-09, Vol.184 (20), p.5179-5188.e8

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. In four instances, there was evidence for onward transmission of a recombinant-origin virus, including one transmission cluster of 45 sequenced cases over the course of 2 months. The inferred genomic locations of recombination breakpoints suggest that every community-transmitted recombinant virus inherited its spike region from a B.1.1.7 parental virus, consistent with a transmission advantage for B.1.1.7’s set of mutations. [Display omitted] •We find evidence for recombination in SARS-CoV-2•We identify eight clear recombination events, four of which lead to onward transmission•Estimated breakpoints are consistent with coronavirus cellular replication dynamics•Transmitted recombinants inherited the more-transmissible B.1.1.7 spike gene Sampling from late 2020 to early 2021 provides evidence for SARS-CoV-2 recombination and onward community transmission of recombinant viruses that inherited the spike region from the B.1.1.7 (alpha) variant.