Details

Autor(en) / Beteiligte

• Ştefan, Alina Elena
• Gologan, Daniela
• Leavitt, Matthew O.
• Muşat, Sorin
• Pleşea, Iancu Emil
• Stan, Liane Gloria Raluca
• Pleşea, Răzvan Mihail
• Militaru, Manuella

Titel

Tissue microarrays – brief history, techniques and clinical future

Ist Teil von

• Romanian journal of morphology and embryology, 2020-10, Vol.61 (4), p.1077-1083

Ort / Verlag

Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest

Erscheinungsjahr

2020

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Introduction and Aim : There is a growing need for better, cheaper and faster histopathological diagnostic. The authors reviewed the main steps of the efforts towards the improvement of the pre-analytical phase of tissue processing for histological examination. Results : Since their introduction decades ago tissue microarrays (TMAs) proved their value by increasing efficiency, standardization and accuracy of many histological techniques, such as histochemistry, histoenzymology, immunohistochemistry, in situ hybridization, etc. By allowing the simultaneous analysis and comparison of multiple different tissues on a single histology slide (up to 1000 individual samples), TMAs are also having a significant economic advantage (consumables and labor). From its first description until recent years, the TMA techniques have evolved steadily but slowly despite many attempts to adapt it for clinical diagnostics. In this paper, we are reviewing the main techniques of obtaining TMA blocks from the beginning to the present day, as well as recent developments that are expanding their scope into high accuracy/efficiency clinical diagnostics. Conclusions : Considering recent developments, we believe that the prospect of high-throughput histology might be achievable in the not-so-distant future.