Details

Autor(en) / Beteiligte

• Chung, Edmund Y.M.
• Palmer, Suetonia C.
• Natale, Patrizia
• Krishnan, Anoushka
• Cooper, Tess E.
• Saglimbene, Valeria M.
• Ruospo, Marinella
• Au, Eric
• Jayanti, Sumedh
• Liang, Amy
• Jie Deng, Danny Jia
• Chui, Juanita
• Higgins, Gail Y.
• Tong, Allison
• Wong, Germaine
• Teixeira-Pinto, Armando
• Hodson, Elisabeth M.
• Craig, Jonathan C.
• Strippoli, Giovanni F.M.

Titel

Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis

Ist Teil von

• American journal of kidney diseases, 2021-12, Vol.78 (6), p.804-815

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Coronavirus disease 2019 (COVID-19) disproportionately affects people with chronic diseases such as chronic kidney disease (CKD). We assessed the incidence and outcomes of COVID-19 in people with CKD. Systematic review and meta-analysis by searching MEDLINE, EMBASE, and PubMed through February 2021. People with CKD with or without COVID-19. Cohort and case-control studies. Incidences of COVID-19, death, respiratory failure, dyspnea, recovery, intensive care admission, hospital admission, need for supplemental oxygen, hospital discharge, sepsis, short-term dialysis, acute kidney injury, and fatigue. Random-effects meta-analysis and evidence certainty adjudicated using an adapted version of GRADE (Grading of Recommendations Assessment, Development and Evaluation). 348 studies (382,407 participants with COVID-19 and CKD; 1,139,979 total participants with CKD) were included. Based on low-certainty evidence, the incidence of COVID-19 was higher in people with CKD treated with dialysis (105 per 10,000 person-weeks; 95% CI, 91-120; 95% prediction interval [PrI], 25-235; 59 studies; 468,233 participants) than in those with CKD not requiring kidney replacement therapy (16 per 10,000 person-weeks; 95% CI, 4-33; 95% PrI, 0-92; 5 studies; 70,683 participants) or in kidney or pancreas/kidney transplant recipients (23 per 10,000 person-weeks; 95% CI, 18-30; 95% PrI, 2-67; 29 studies; 120,281 participants). Based on low-certainty evidence, the incidence of death in people with CKD and COVID-19 was 32 per 1,000 person-weeks (95% CI, 30-35; 95% PrI, 4-81; 229 studies; 70,922 participants), which may be higher than in people with CKD without COVID-19 (incidence rate ratio, 10.26; 95% CI, 6.78-15.53; 95% PrI, 2.62-40.15; 4 studies; 18,347 participants). Analyses were generally based on low-certainty evidence. Few studies reported outcomes in people with CKD without COVID-19 to calculate the excess risk attributable to COVID-19, and potential confounders were not adjusted for in most studies. The incidence of COVID-19 may be higher in people receiving maintenance dialysis than in those with CKD not requiring kidney replacement therapy or those who are kidney or pancreas/kidney transplant recipients. People with CKD and COVID-19 may have a higher incidence of death than people with CKD without COVID-19.