Details

Autor(en) / Beteiligte

• Blessin, Niclas C.
• Li, Wenchao
• Mandelkow, Tim
• Jansen, Hannah L.
• Yang, Cheng
• Raedler, Jonas B.
• Simon, Ronald
• Büscheck, Franziska
• Dum, David
• Luebke, Andreas M.
• Hinsch, Andrea
• Möller, Katharina
• Menz, Anne
• Bernreuther, Christian
• Lebok, Patrick
• Clauditz, Till
• Sauter, Guido
• Marx, Andreas
• Uhlig, Ria
• Wilczak, Waldemar
• Minner, Sarah
• Krech, Till
• Fraune, Christoph
• Höflmayer, Doris
• Burandt, Eike
• Steurer, Stefan

Titel

Prognostic role of proliferating CD8+ cytotoxic Tcells in human cancers

Ist Teil von

• Cellular oncology (Dordrecht), 2021-08, Vol.44 (4), p.793-803

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2021

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Purpose Expansion of CD8 + cytotoxic Tlymphocytes is a prerequisite for anti-cancer immune activity and has gained interest in the era of immune checkpoint therapy. Methods To understand the CD8 + T cell dynamics in the tumor microenvironment, we used multiplex fluorescence immunohistochemistry to quantitate CD8 + proliferation (Ki67 co-expression) in tissue microarrays from 1107 colorectal, 642 renal cell, 1066 breast, 375 ovarian, 451 pancreatic and 347 gastric cancer samples. Results The density and the percentage of proliferating (Ki67 + ) CD8 + T cells were both highly variable between tumor types as well as between patients with the same tumor type. Elevated density and percentage of proliferating CD8 + cytotoxic T cells were significantly associated with favorable tumor parameters such as low tumor stage, negative nodal stage ( p  ≤ 0.0041 each), prolonged overall survival ( p  ≤ 0.0028 each) and an inflamed immune phenotype ( p  = 0.0025) in colorectal cancer and, in contrast, linked to high tumor stage, advanced ISUP/Fuhrman/Thoenes grading (each p  ≤ 0.003), shorter overall survival ( p  ≤ 0.0330 each) and an immune inflamed phenotype ( p  = 0.0094) in renal cell cancer. In breast, ovarian, pancreatic and gastric cancer the role of (Ki67 + )CD8 + Tcells was not linked to clinicopathological data. Conclusion Our data demonstrate a tumor type dependent prognostic impact of proliferating (Ki67 + )CD8 + Tcells and an inverse impact in colorectal and renal cell cancer.