Details

Autor(en) / Beteiligte

• Vegezzi, Elisa
• Ravaglia, Sabrina
• Buongarzone, Gabriele
• Bini, Paola
• Diamanti, Luca
• Gastaldi, Matteo
• Prunetti, Paolo
• Rognone, Elisa
• Marchioni, Enrico

Titel

Acute myelitis and ChAdOx1 nCoV-19 vaccine: Casual or causal association?

Ist Teil von

• Journal of neuroimmunology, 2021-10, Vol.359, p.577686-577686, Article 577686

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A 44-year-old previously healthy woman developed acute myelitis in close temporal relationship with ChAdOx1 nCoV-19 vaccine first-dose administration. The neurological involvement was mainly sensory with neuroimaging showing two mono-metameric lesions involving the posterior and lateral cord at dorsal level. Significant improvement was promptly recorded with high-dose intravenous steroids, with complete recovery within one month. The strict temporal relationship between vaccination and myelitis, together with the absence of clues pointing to alternative diagnoses, might suggest a conceivable role for anti-SARS-CoV-2 vaccine as immunological trigger, although a causal relationship has yet to be established and our preliminary observation suggests caution. [Display omitted] •Vaccine-related autoimmunity has been an interesting and rather complex matter of debate for years.•Any adverse event can be defined as vaccine-induced if peculiar requirements are met i.e., temporal association, consistency, specificity and strength.•We report on a patient with an inflammatory myelopathy in close temporal relationship with the first-dose of ChAdOx1 nCoV-19 vaccine administration.•The short interval between the onset of symptoms and the vaccination might point to a non-specific immunological mechanism of bystander activation.•Our preliminary observation suggests caution and further confirmation in larger cohorts is needed.