Details

Autor(en) / Beteiligte

• Du, Sisi
• Wu, Xiaojing
• Li, Binbin
• Wang, Yimin
• Shang, Lianhan
• Huang, Xu
• Xia, Yudi
• Yu, Donghao
• Lu, Naicong
• Liu, Zhibo
• Wang, Chunlei
• Liu, Xinmeng
• Xiong, Zhujia
• Zou, Xiaohui
• Lu, Binghuai
• Liu, Yingmei
• Zhan, Qingyuan
• Cao, Bin

Titel

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia

Ist Teil von

• Frontiers of medicine, 2022-06, Vol.16 (3), p.389-402

Ort / Verlag

Beijing: Higher Education Press

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia (SCAP). We prospectively enrolled consecutive SCAP patients admitted to ICU. Bronchoscopy was performed at bedside within 48 h of ICU admission, and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid. The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy. Sixty-seven patients were included. Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota (R 2=0.033; P=0.018), followed by acute kidney injury (AKI; R 2=0.032; P=0.011) and plasma MIP-1β level (R 2=0.027; P=0.044). Random forest identified that the families Prevotellaceae, Moraxellaceae, and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results. Multivariable Cox regression showed that the increase in α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements. The positive bacteria lab test results, AKI, and plasma MIP-1β level were associated with patients' lung microbiota composition on ICU admission. The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.