Details

Autor(en) / Beteiligte

• KAWASHIMA, Yuuto
• FUJIMOTO, Ayako
• SAITO, Morihiro
• MIKAMI, Osamu
• ISHIKAWA, Yoshiharu
• KADOTA, Koichi

Titel

Histological comparison of malignant epithelioid mesothelioma in young and adult cattle

Ist Teil von

• Journal of Veterinary Medical Science, 2021, Vol.83(6), pp.968-972

Ort / Verlag

JAPANESE SOCIETY OF VETERINARY SCIENCE

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The histology and immunohistochemistry of pleomorphic and conventional epithelioid mesotheliomas were examined. The former was detected in two young calves aged 2 and 4 months and was characterized by pleomorphic and atypical cells with decreased expression of cytokeratin 7 (CK7). In contrast, the latter was found in a 31-month-old heifer, consisting of tumor cells uniform in size and shape with CK7 expression in nearly all cells. Production of collagen by tumor cells was demonstrated in both histological types, and was considered to be characteristic of bovine epithelioid mesothelioma. Pleomorphic mesothelioma is far more pleomorphic and mitotically active than conventional mesothelioma, and its normal counterpart may be immature mesothelial cells with high proliferation potential, which exist in fetal life and early calfhood.