Details

Autor(en) / Beteiligte

• Gopal, Akshita B
• Chakraborty, Soumyadeep
• Padhan, Pratyush K
• Barik, Alok
• Dixit, Pragyesh
• Chakraborty, Debashish
• Poirah, Indrajit
• Samal, Supriya
• Sarkar, Arup
• Bhattacharyya, Asima

Titel

Silent hypoxia in COVID-19: a gut microbiota connection

Ist Teil von

• Current opinion in physiology, 2021-10, Vol.23, p.100456-100456, Article 100456

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •SARS-CoV-2-mediated gut dysbiosis disrupts production of SCFA and other metabolites.•Dysbiosis causes inflammation and intestinal barrier as well as blood-brain barrier damage.•Neuromodulators from dysbiotic gut might affect the CNS or CB causing silent hypoxia. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has triggered the COVID-19 pandemic. Several factors induce hypoxia in COVID-19. Despite being hypoxic, some SARS-CoV-2-infected individuals do not experience any respiratory distress, a phenomenon termed ‘silent (or happy) hypoxia’. Prolonged undetected hypoxia could be dangerous, sometimes leading to death. A few studies attempted to unravel what causes silent hypoxia, however, the exact mechanisms are still elusive. Here, we aim to understand how SARS-CoV-2 causes silent hypoxia.