Details

Autor(en) / Beteiligte

• Townsley, Samantha M.
• Donofrio, Gina C.
• Jian, Ningbo
• Leggat, David J.
• Dussupt, Vincent
• Mendez-Rivera, Letzibeth
• Eller, Leigh Anne
• Cofer, Lauryn
• Choe, Misook
• Ehrenberg, Philip K.
• Geretz, Aviva
• Gift, Syna
• Grande, Rebecca
• Lee, Anna
• Peterson, Caroline
• Piechowiak, Mary Bryson
• Slike, Bonnie M.
• Tran, Ursula
• Joyce, M. Gordon
• Georgiev, Ivelin S.
• Rolland, Morgane
• Thomas, Rasmi
• Tovanabutra, Sodsai
• Doria-Rose, Nicole A.
• Polonis, Victoria R.
• Mascola, John R.
• McDermott, Adrian B.
• Michael, Nelson L.
• Robb, Merlin L.
• Krebs, Shelly J.

Titel

B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies

Ist Teil von

• Cell host & microbe, 2021-04, Vol.29 (4), p.564-578.e9

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Determining which immunological mechanisms contribute to the development of broad neutralizing antibodies (bNAbs) during HIV-1 infection is a major goal to inform vaccine design. Using samples from a longitudinal HIV-1 acute infection cohort, we found key B cell determinants within the first 14–43 days of viremia that predict the development of bNAbs years later. Individuals who develop neutralization breadth had significantly higher B cell engagement with the autologous founder HIV envelope (Env) within 1 month of initial viremia. A higher frequency of founder-Env-specific naive B cells was associated with increased B cell activation and differentiation and predictive of bNAb development. These data demonstrate that the initial B cell interaction with the founder HIV Env is important for the development of broadly neutralizing antibodies and provide evidence that events within HIV acute infection lead to downstream functional outcomes. [Display omitted] •A reduction in total peripheral B cells associates with HIV neutralization breadth•The initial interaction of founder Env with naive B cells predicts bNAb development•Increased B cell engagement with founder Env increases activation and differentiation Investigating how HIV-infected patients develop broadly neutralizing antibodies can inform vaccine design. Townsley et al. show that elevated B cell interactions with the HIV founder envelope glycoprotein within the first month of infection lead to increased B cell activation and differentiation, which predict development of neutralization breadth years later.