Details

Autor(en) / Beteiligte

• Almanzar, Nicole
• Antony, Jane
• Baghel, Ankit S
• Bakerman, Isaac
• Bansal, Ishita
• Barres, Ben A
• Beachy, Philip A

Titel

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Ist Teil von

• Nature (London), 2020-07, Vol.583 (7817), p.590-595

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death . Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood . To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing-such as senescence , genomic instability and changes in the immune system . This transcriptomic atlas-which we denote Tabula Muris Senis, or 'Mouse Ageing Cell Atlas'-provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.