Details

Autor(en) / Beteiligte

• Abizaid, Alexandre
• Campos, Carlos M.
• Guimarães, Patrícia O.
• Costa, José de Ribamar
• Falcão, Breno A. A.
• Mangione, Fernanda
• Caixeta, Adriano
• Lemos, Pedro A.
• Brito, Fabio S.
• Cavalcante, Ricardo
• Bezerra, Cristiano Guedes
• Cortes, Leandro
• Ribeiro, Henrique B.
• Souza, Francis R.
• Huemer, Natassja
• Val, Renata M.
• Caramelli, Bruno
• Calderaro, Daniela
• Lima, Felipe G.
• Hajjar, Ludhmila A.
• Mehran, Roxana
• Filho, Roberto Kalil

Titel

Patients with COVID‐19 who experience a myocardial infarction have complex coronary morphology and high in‐hospital mortality: Primary results of a nationwide angiographic study

Ist Teil von

• Catheterization and cardiovascular interventions, 2021-09, Vol.98 (3), p.E370-E378

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objectives We aimed to explore angiographic patterns and in‐hospital outcomes of patients with concomitant coronavirus disease‐19 (COVID‐19) and myocardial infarction (MI). Background Patients with COVID‐19 may experience MI during the course of the viral infection. However, this association is currently poorly understood. Methods This is a multicenter prospective study of consecutive patients with concomitant COVID‐19 and MI who underwent coronary angiography. Quantitative and qualitative coronary angiography were analyzed by two observers in an independent core lab. Results A total of 152 patients were included, of whom 142 (93.4%) had COVID‐19 diagnosis confirmation. The median time between symptom onset and hospital admission was 5 (1–10) days. A total of 83 (54.6%) patients presented with ST‐elevation MI. The median angiographic Syntax score was 16 (9.0–25.3) and 69.0% had multi‐vessel disease. At least one complex lesion was found in 73.0% of patients, 51.3% had a thrombus containing lesion, and 57.9% had myocardial blush grades 0/1. The overall in‐hospital mortality was 23.7%. ST‐segment elevation MI presentation and baseline myocardial blush grades 0 or 1 were independently associated with a higher risk of death (HR 2.75, 95%CI 1.30–5.80 and HR 3.73, 95%CI 1.61–8.61, respectively). Conclusions Patients who have a MI in the context of ongoing COVID‐19 mostly present complex coronary morphologies, implying a background of prior atherosclerotic disease superimposed on a thrombotic milieu. The in‐hospital prognosis is poor with a markedly high mortality, prompting further investigation to better clarify this newly described condition.