Details

Autor(en) / Beteiligte

• Boroujeni, Mahdi Eskandarian
• Simani, Leila
• Bluyssen, Hans A. R
• Samadikhah, Hamid Reza
• Zamanlui Benisi, Soheila
• Hassani, Sanaz
• Akbari Dilmaghani, Nader
• Fathi, Mobina
• Vakili, Kimia
• Mahmoudiasl, Gholam-Reza
• Abbaszadeh, Hojjat Allah
• Hassani Moghaddam, Meysam
• Abdollahifar, Mohammad-Amin
• Aliaghaei, Abbas

Titel

Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19

Ist Teil von

• ACS chemical neuroscience, 2021-06, Vol.12 (12), p.2143-2150

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected people worldwide. A growing body of literature suggests the neurological complications and manifestations in response to COVID-19 infection. Herein, we explored the inflammatory and immune responses in the post-mortem cerebral cortex of patients with severe COVID-19. The participants comprised three patients diagnosed with severe COVID-19 from March 26, 2020, to April 17, 2020, and three control patients. Our findings demonstrated a surge in the number of reactive astrocytes and activated microglia, as well as low levels of glutathione along with the upregulation of inflammation- and immune-related genes IL1B, IL6, IFITM, MX1, and OAS2 in the COVID-19 group. Overall, the data imply that oxidative stress may invoke a glial-mediated neuroinflammation, which ultimately leads to neuronal cell death in the cerebral cortex of COVID-19 patients.