The New England journal of medicine, 2021-03, Vol.384 (11), p.1003-1014
- Corey, Lawrence
- Gilbert, Peter B
- Juraska, Michal
- Montefiori, David C
- Morris, Lynn
- Karuna, Shelly T
- Edupuganti, Srilatha
- Mgodi, Nyaradzo M
- deCamp, Allan C
- Rudnicki, Erika
- Huang, Yunda
- Gonzales, Pedro
- Cabello, Robinson
- Orrell, Catherine
- Lama, Javier R
- Laher, Fatima
- Lazarus, Erica M
- Sanchez, Jorge
- Frank, Ian
- Hinojosa, Juan
- Sobieszczyk, Magdalena E
- Marshall, Kyle E
- Mukwekwerere, Pamela G
- Makhema, Joseph
- Baden, Lindsey R
- Mullins, James I
- Williamson, Carolyn
- Hural, John
- McElrath, M. Juliana
- Bentley, Carter
- Takuva, Simbarashe
- Gomez Lorenzo, Margarita M
- Burns, David N
- Espy, Nicole
- Randhawa, April K
- Kochar, Nidhi
- Piwowar-Manning, Estelle
- Donnell, Deborah J
- Sista, Nirupama
- Andrew, Philip
- Kublin, James G
- Gray, Glenda
- Ledgerwood, Julie E
- Mascola, John R
- Cohen, Myron S
2021
Details
- Autor(en) / Beteiligte
- Corey, Lawrence
- Gilbert, Peter B
- Juraska, Michal
- Montefiori, David C
- Morris, Lynn
- Karuna, Shelly T
- Edupuganti, Srilatha
- Mgodi, Nyaradzo M
- deCamp, Allan C
- Rudnicki, Erika
- Huang, Yunda
- Gonzales, Pedro
- Cabello, Robinson
- Orrell, Catherine
- Lama, Javier R
- Laher, Fatima
- Lazarus, Erica M
- Sanchez, Jorge
- Frank, Ian
- Hinojosa, Juan
- Sobieszczyk, Magdalena E
- Marshall, Kyle E
- Mukwekwerere, Pamela G
- Makhema, Joseph
- Baden, Lindsey R
- Mullins, James I
- Williamson, Carolyn
- Hural, John
- McElrath, M. Juliana
- Bentley, Carter
- Takuva, Simbarashe
- Gomez Lorenzo, Margarita M
- Burns, David N
- Espy, Nicole
- Randhawa, April K
- Kochar, Nidhi
- Piwowar-Manning, Estelle
- Donnell, Deborah J
- Sista, Nirupama
- Andrew, Philip
- Kublin, James G
- Gray, Glenda
- Ledgerwood, Julie E
- Mascola, John R
- Cohen, Myron S
- Titel
- Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition
- Ist Teil von
- The New England journal of medicine, 2021-03, Vol.384 (11), p.1003-1014
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Two phase 2 trials assessed the efficacy and safety of intravenous infusions of a broadly neutralizing antibody, VRCO1, to prevent HIV-1 infection. VRC01 did not cause adverse events and did not prevent overall HIV-1 acquisition significantly more effectively than placebo. In secondary analyses, VRC01 prevented transmission of VRC01-sensitive HIV-1 isolates.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa2031738Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8189692
- Format
- –
- Schlagworte
- Adolescent, Adult, Adverse events, Africa South of the Sahara - epidemiology, Allergies, Americas - epidemiology, Antibiotics, Antibodies, Antibodies, Monoclonal - adverse effects, Antibodies, Monoclonal - therapeutic use, Binding sites, Broadly Neutralizing Antibodies - adverse effects, Broadly Neutralizing Antibodies - therapeutic use, Collaboration, Confidence intervals, Design, Double-Blind Method, Drug therapy, Enrollments, Europe - epidemiology, Female, HIV, HIV Antibodies - adverse effects, HIV Antibodies - therapeutic use, HIV infection, HIV Infections - epidemiology, HIV Infections - prevention & control, HIV-1 - drug effects, Human immunodeficiency virus, Humans, Incidence, Infections, Infectious diseases, Male, Medical research, Medical tests, Patient outcomes, Placebos, Prevention, Proof of Concept Study, Prophylaxis, Protocol, Statistical analysis, Testing, Transgender persons, Young Adult