Details

Autor(en) / Beteiligte

• Nakamura, Tomonori
• Fujiwara, Kohei
• Saitou, Mitinori
• Tsukiyama, Tomoyuki

Titel

Non-human primates as a model for human development

Ist Teil von

• Stem cell reports, 2021-05, Vol.16 (5), p.1093-1103

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Human development has been studied for over a century, but the molecular mechanisms underlying human embryogenesis remain largely unknown due to technical difficulties and ethical issues. Accordingly, mice have been used as a model for mammalian development and studied extensively to infer human biology based on the conservation of fundamental processes between the two species. As research has progressed, however, species-specific differences in characteristics between rodents and primates have become apparent. Non-human primates (NHPs) have also been used for biomedical research, and are now attracting attention as a model for human development. Here, we summarize primate species from the evolutionary and genomic points of view. Then we review the current issues and progress in gene modification technology for NHPs. Finally, we discuss recent studies on the early embryogenesis of primates and future perspectives. In this article, Nakamura, Tsukiyama, and colleagues summarize primate species from an evolutionary and genomic point of view, and review the current issues and progress in gene modification technology for non-human primates. They also discuss recent studies of the early embryogenesis of primates and future perspectives.