The New England journal of medicine, 2021-06, Vol.384 (22), p.2124-2130
2021
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Details
- Autor(en) / Beteiligte
- Titel
- Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
- Ist Teil von
- The New England journal of medicine, 2021-06, Vol.384 (22), p.2124-2130
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2021
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- This report describes a very rare but life-threatening sequela of vaccination with ChAdOx1 nCoV-19. Within 10 days after a first injection, five health care workers presented with thrombocytopenia and thromboses, including cerebral venous sinus thrombosis with catastrophic outcome. The apparent cause is an anti-PF4 antibody capable of platelet activation; intravenous immune globulin may be therapeutic.
- Sprache
- Englisch; Norwegisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa2104882Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8112568
- Format
- –
- Schlagworte
- Abdomen, Adult, Antibodies, Anticoagulants, Autoantibodies - blood, Autoimmune Diseases - etiology, Blood Chemical Analysis, Blood platelets, ChAdOx1 nCoV-19, Consent, Coronaviruses, COVID-19, COVID-19 vaccines, COVID-19 Vaccines - adverse effects, Edema, Enzyme-Linked Immunosorbent Assay, Fatal Outcome, Female, Headaches, Health care, Hemorrhage, Heparin, Hospitals, Humans, Immune response, Immunization, Intracranial pressure, Male, Medical imaging, Medical personnel, Middle Aged, Original, Patients, Platelet Aggregation, Platelet Count, Platelet factor 4, Platelet Factor 4 - immunology, Proteins, Severe acute respiratory syndrome coronavirus 2, Sinuses, Stroke, Thrombocytopenia, Thrombocytopenia - etiology, Thrombosis, Thrombosis - etiology, Vaccination, Vaccines, Veins & arteries