The New England journal of medicine, 2021-06, Vol.384 (23), p.2202-2211
2021
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Details
- Autor(en) / Beteiligte
- Titel
- Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination
- Ist Teil von
- The New England journal of medicine, 2021-06, Vol.384 (23), p.2202-2211
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2021
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Scully and colleagues report 23 cases of abnormal clotting, primarily involving the cerebral veins, 6 to 24 days after the first dose of the ChAdOx1 nCoV-19 vaccine. The syndrome was incited by antibodies to platelet factor 4, independent of heparin therapy. Early recognition and avoidance of platelet transfusion are key.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa2105385Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8112532
- Format
- –
- Schlagworte
- Adult, Adverse events, Aged, Algorithms, Antibodies, Antibodies, Viral - blood, Anticoagulants, Anticoagulants - adverse effects, Autoantibodies - blood, Blood platelets, ChAdOx1 nCoV-19, Coronaviruses, COVID-19, COVID-19 - prevention & control, COVID-19 vaccines, COVID-19 Vaccines - adverse effects, COVID-19 Vaccines - immunology, Enzymes, Female, Fibrinogen, Flow Cytometry, Globulins, Hemorrhage, Heparin, Heparin - adverse effects, Humans, Immunization, Immunoglobulins, Intravenous administration, Laboratories, Male, Middle Aged, Original, Pandemics, Patients, Phenotypes, Platelet factor 4, Platelet Factor 4 - immunology, Platelets, Proteins, Pulmonary embolisms, Severe acute respiratory syndrome coronavirus 2, Thrombocytopenia, Thrombocytopenia - etiology, Thrombocytopenia - immunology, Thromboembolism, Thrombophilia, Thrombosis, Thrombosis - etiology, Thrombosis - immunology, Vaccines