Details

Autor(en) / Beteiligte

• Colozza, Gabriele
• Koo, Bon-Kyoung

Titel

Ub and Dub of RNF43/ZNRF3 in the WNT signalling pathway

Ist Teil von

• EMBO reports, 2021-05, Vol.22 (5), p.e52970-n/a

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2021

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• The E3 ubiquitin ligases RING finger protein 43 (RNF43) and zinc and RING finger 3 (ZNRF3) have received great attention for their critical role in regulating WNT signalling during adult stem cell homeostasis. By promoting the turnover of WNT receptors, Frizzled and LRP5/6, RNF43 and ZNRF3 ensure that proper levels of WNT activity are maintained in stem cells. The molecular mechanism of RNF43/ZNRF3 activity is beginning to emerge from several recent studies, yet little is known about the regulation of RNF43/ZNRF3 at the post-translational level. A study in this issue of EMBO Reports identifies the deubiquitinating enzyme USP42 as a key regulator of WNT signalling, which acts by antagonizing the ubiquitin-dependent clearance of RNF43/ZNRF3 induced by R-spondins (Giebel et al , 2021). Graphical Abstract A study in this issue implicates the deubiquitinating enzyme USP42 in Wnt signalling. USP42 stabilizes RNF43/ZNRF3 at the cell surface, resulting in increased turnover of LRP6 and Frizzled and the inhibition of Wnt signalling.