Details

Autor(en) / Beteiligte

• da Silva Antunes, Ricardo
• Pallikkuth, Suresh
• Williams, Erin
• Dawen Yu, Esther
• Mateus, Jose
• Quiambao, Lorenzo
• Wang, Eric
• Rawlings, Stephen A
• Stadlbauer, Daniel
• Jiang, Kaijun
• Amanat, Fatima
• Arnold, David
• Andrews, David
• Fuego, Irma
• Dan, Jennifer M
• Grifoni, Alba
• Weiskopf, Daniela
• Krammer, Florian
• Crotty, Shane
• Hoffer, Michael E
• Pahwa, Savita G
• Sette, Alessandro

Titel

Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers

Ist Teil von

• The Journal of infectious diseases, 2021-07, Vol.224 (1), p.70-80

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2021

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC-reactive T cells in SARS-CoV-2–seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 T-cell reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC T-cell reactivity was decreased in SARS-CoV-2–infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego. CD4+ T-cell responses against common cold coronaviruses (CCC) are elevated in SARS-CoV-2 seronegative high-risk health care workers (HCW) compared to COVID-19 convalescent HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses and/or cross-reactivity associated with a protective effect. CD4+ T-cell responses against common cold coronaviruses (CCC) are elevated in SARS-CoV-2 seronegative high-risk health care workers (HCW) compared to COVID-19 convalescent HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses and/or cross-reactivity a protective effect.