Details

Autor(en) / Beteiligte

• Al Qahtani, Mohammed S
• Bojal, Shoukat A
• Alqarzaie, Abdullah A
• Alqahtani, Abdulaziz A

Titel

Insulinoma in tuberous sclerosis: An entity not to be missed

Ist Teil von

• Saudi medical journal, 2021-03, Vol.42 (3), p.332-337

Ort / Verlag

Saudi Arabia: Saudi Medical Journal

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Pancreatic neuroendocrine tumors are rare with an incident rate of 5 cases per million individuals. Tuberous sclerosis complex is an autosomal dominant disease. This disease involves multisystem and occurs in one out of every 6,000-10,000 individuals. In this study, we describe a 47-year-old male known tuberous sclerosis patient with an insulinoma. The tumor was incidentally detected in follow-up imaging for a previous ampulla of Vater tubular adenoma. However, the patient reported symptoms of hypoglycemia. The insulinoma was enucleated successfully. Histopathology revealed a well-differentiated, grade one neuroendocrine tumor measuring around 2 cm in diameter. Seven cases were reported in the literature of tuberous sclerosis-associated insulinoma. The 7 reported cases had different hypoglycemia related symptoms. The reported tumors varied in size and location on the pancreas. This paper details the eighth case worldwide where an insulinoma occurred in a tuberous sclerosis patient.