Details

Autor(en) / Beteiligte

• Ahmadi, Mohsen
• Pashangzadeh, Salar
• Mousavi, Pegah
• Saffarzadeh, Negin
• Amin Habibi, Mohammad
• Hajiesmaeili, Fatemeh
• Rezaei, Nima

Titel

ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19

Ist Teil von

• International immunopharmacology, 2021-06, Vol.95, p.107568-107568, Article 107568

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• •ACE2 is overexpressed in colon cancer tissues.•Colon cancer patients may have a higher risk for COVID-19 infection.•Upregulation of ACE is correlated with immune cell infiltration levels in COAD.•COVID-19 may change the prognosis of COAD patients by immune-related mechanisms. Novel coronavirus disease (COVID-19) pandemic has become a global health emergency. It has been reported that a few conditions, including cancer, predispose individuals to SARS-CoV-2 infection and severe form of COVID-19. These findings led us to evaluate the susceptibility of colon adenocarcinoma (COAD) patients to SARS-CoV-2 infection by investigating ACE2 expression in their tumor tissues. The expression analysis revealed that both mRNA and protein levels of ACE2 had increased in colon cancer samples than normal group. Next, the prognosis analysis has indicated that the upregulation of ACE2 was not correlated with patient survival outcomes. Further assessment displayed the hypomethylation of the ACE2 gene promoter in COAD patients. This methylation status has a strong negative correlation with ACE2 gene expression. The functional enrichment analysis of the genes that had similar expression patterns with ACE2 in colon cancer tissues demonstrated that they mainly enriched in Vitamin digestion and absorption pathway. Finally, we found that ACE2 gene expression had a significant association with the immune cell infiltration levels in COAD patients. In conclusion, it has plausible that COAD patients are more likely to be infected with SARS-CoV-2 and experience severe injuries. Moreover, COVID-19 would bring unfavorable survival outcomes for patients with colon cancer by way of immune cell infiltration linked process. The present study highlights the importance of preventiveactionsfor COAD patients during the COVID-19 pandemic.