Details

Autor(en) / Beteiligte

• Hoffmann, Markus
• Arora, Prerna
• Groß, Rüdiger
• Seidel, Alina
• Hörnich, Bojan F.
• Hahn, Alexander S.
• Krüger, Nadine
• Graichen, Luise
• Hofmann-Winkler, Heike
• Kempf, Amy
• Winkler, Martin S.
• Schulz, Sebastian
• Jäck, Hans-Martin
• Jahrsdörfer, Bernd
• Schrezenmeier, Hubert
• Müller, Martin
• Kleger, Alexander
• Münch, Jan
• Pöhlmann, Stefan

Titel

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Ist Teil von

• Cell, 2021-04, Vol.184 (9), p.2384-2393.e12

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the COVID-19 pandemic. However, the recently emerged SARS-CoV-2 variants B.1.1.7 (UK), B.1.351 (South Africa), and P.1 (Brazil) harbor mutations in the viral spike (S) protein that may alter virus-host cell interactions and confer resistance to inhibitors and antibodies. Here, using pseudoparticles, we show that entry of all variants into human cells is susceptible to blockade by the entry inhibitors soluble ACE2, Camostat, EK-1, and EK-1-C4. In contrast, entry of the B.1.351 and P.1 variant was partially (Casirivimab) or fully (Bamlanivimab) resistant to antibodies used for COVID-19 treatment. Moreover, entry of these variants was less efficiently inhibited by plasma from convalescent COVID-19 patients and sera from BNT162b2-vaccinated individuals. These results suggest that SARS-CoV-2 may escape neutralizing antibody responses, which has important implications for efforts to contain the pandemic. [Display omitted] •B.1.1.7, B.1.351, and P.1 do not show augmented host cell entry•Entry inhibitors under clinical evaluation block all variants•B.1.351 and P.1 can escape from therapeutic antibodies•B.1.351 and P.1 evade antibodies induced by infection and vaccination Comparison of the SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 shows that inhibitors under clinical evaluation are still effective in blocking entry, though the B.1.351 and P.1 variants evade antibody responses induced upon infection as well as vaccination and evade certain therapeutic antibodies.