Details

Autor(en) / Beteiligte

• Williams, Philip
• McWilliams, Chris
• Soomro, Kamran
• Harding, Irasha
• Gurney, Stefan
• Thomas, Matt
• Albur, Maha
• Martin Williams, O.

Titel

The dynamics of procalcitonin in COVID-19 patients admitted to Intensive care unit - a multi-centre cohort study in the South West of England, UK

Ist Teil von

• The Journal of infection, 2021-06, Vol.82 (6), p.e24-e26

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •We have undertaken a retrospective observational study describing the dynamics of PCT and CRP, including the response to antibiotic treatment, in adults with severe COVID-19 infection requiring ICU admission.•Results were compared to two better-understood groups of patients from historical data, adult ICU patients with either bacteraemia or influenza.•Elevated PCT in the first 48 h of admission was rare in COVID-19 patients. Where PCT was recorded it was <1.0 ng/L in 68.9% of COVID compared to 38% influenza patients.•PCT was low throughout the study, or responded rapidly to antibiotics 65.4% and 82.6% of COVID-19 and influenza patients respectively.•The dynamics of PCT in COVID-19 patients are consistent with a response to secondary bacterial infection and are not consistent with an inflammatory response to COVID-19 alone, and in contrast to CRP, PCT appears to be a useful biomarker in identifying COVID-19 patients with super-added bacterial.