Details

Autor(en) / Beteiligte

• KRUER, M. C
• BODDAERT, N
• SCHNEIDER, S. A
• HOULDEN, H
• BHATIA, K. P
• GREGORY, A
• ANDERSON, J. C
• ROONEY, W. D
• HOGARTH, P
• HAYFLICK, S. J

Titel

Neuroimaging Features of Neurodegeneration with Brain Iron Accumulation

Ist Teil von

• American journal of neuroradiology : AJNR, 2012-03, Vol.33 (3), p.407-414

Ort / Verlag

Oak Brook, IL: American Society of Neuroradiology

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• NBIA characterizes a class of neurodegenerative diseases that feature a prominent extrapyramidal movement disorder, intellectual deterioration, and a characteristic deposition of iron in the basal ganglia. The diagnosis of NBIA is made on the basis of the combination of representative clinical features along with MR imaging evidence of iron accumulation. In many cases, confirmatory molecular genetic testing is now available as well. A number of new subtypes of NBIA have recently been described, with distinct neuroradiologic and clinical features. This article outlines the known subtypes of NBIA, delineates their clinical and radiographic features, and suggests an algorithm for evaluation.