Details

Autor(en) / Beteiligte

• McNamara, A L
• Dickerson, E C
• Gomez-Hassan, D M
• Cinti, S K
• Srinivasan, A

Titel

Yield of Image-Guided Needle Biopsy for Infectious Discitis: A Systematic Review and Meta-Analysis

Ist Teil von

• American journal of neuroradiology : AJNR, 2017-10, Vol.38 (10), p.2021-2027

Ort / Verlag

United States: American Society of Neuroradiology

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Image-guided biopsy is routinely conducted in patients with suspected discitis, though the sensitivity reported in the literature ranges widely. We applied a systematic review and meta-analysis to estimate the yield of image-guided biopsy for infectious discitis. We performed a literature search of 4 data bases: PubMed, Cochrane CENTRAL Register of Controlled Trials, Embase.com, and Scopus from data base inception to March 2016. A screen of 1814 articles identified 88 potentially relevant articles. Data were extracted for 33 articles, which were eligible if they were peer-reviewed publications of patients with clinical suspicion of discitis who underwent image-guided biopsy. Patients with positive cultures out of total image-guided biopsy procedures were pooled to estimate yield with 95% confidence intervals. Hypothesis testing was performed with an inverse variance method after logit transformation. Image-guided biopsy has a yield of approximately 48% (793/1763), which is significantly lower than the open surgical biopsy yield of 76% (152/201; < .01). Biopsy in patients with prior antibiotic exposure had a yield of 32% (106/346), which was not significantly different from the yield of 43% (336/813; = .08) in patients without prior antibiotic exposure. The conclusions of this meta-analysis are primarily limited by the heterogeneity of the included studies. Image-guided biopsy has a moderate yield for the diagnosis of infectious discitis, which is significantly lower than the yield of open surgical biopsy. This yield is not significantly affected by prior antibiotic use.