Details

Autor(en) / Beteiligte

• Denison, F C
• Macnaught, G
• Semple, S I K
• Terris, G
• Walker, J
• Anblagan, D
• Serag, A
• Reynolds, R M
• Boardman, J P

Titel

Brain Development in Fetuses of Mothers with Diabetes: A Case-Control MR Imaging Study

Ist Teil von

• American journal of neuroradiology : AJNR, 2017-05, Vol.38 (5), p.1037-1044

Ort / Verlag

United States: American Society of Neuroradiology

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Offspring exposed to maternal diabetes are at increased risk of neurocognitive impairment, but its origins are unknown. With MR imaging, we investigated the feasibility of comprehensive assessment of brain metabolism ( H-MRS), microstructure (DWI), and macrostructure (structural MRI) in third-trimester fetuses in women with diabetes and determined normal ranges for the MR imaging parameters measured. Women with singleton pregnancies with diabetes ( = 26) and healthy controls ( = 26) were recruited prospectively for MR imaging studies between 34 and 38 weeks' gestation. Data suitable for postprocessing were obtained from 79%, 71%, and 46% of women for H-MRS, DWI, and structural MRI, respectively. There was no difference in the NAA/Cho and NAA/Cr ratios (mean [SD]) in the fetal brain in women with diabetes compared with controls (1.74 [0.79] versus 1.79 [0.64], = .81; and 0.78 [0.28] versus 0.94 [0.36], = .12, respectively), but the Cho/Cr ratio was marginally lower (0.46 [0.11] versus 0.53 [0.10], = .04). There was no difference in mean [SD] anterior white, posterior white, and deep gray matter ADC between patients and controls (1.16 [0.12] versus 1.16 [0.08], = .96; 1.54 [0.16] versus 1.59 [0.20], = .56; and 1.49 [0.23] versus 1.52 [0.23], = .89, respectively) or volume of the cerebrum (243.0 mL [22.7 mL] versus 253.8 mL [31.6 mL], = .38). Acquiring multimodal MR imaging of the fetal brain at 3T from pregnant women with diabetes is feasible. Further study of fetal brain metabolism in maternal diabetes is warranted.