The New England journal of medicine, 2021-04, Vol.384 (16), p.1491-1502
- Gordon, Anthony C
- Mouncey, Paul R
- Al-Beidh, Farah
- Rowan, Kathryn M
- Nichol, Alistair D
- Arabi, Yaseen M
- Annane, Djillali
- Beane, Abi
- van Bentum-Puijk, Wilma
- Berry, Lindsay R
- Bhimani, Zahra
- Bonten, Marc J M
- Bradbury, Charlotte A
- Brunkhorst, Frank M
- Buzgau, Adrian
- Cheng, Allen C
- Detry, Michelle A
- Duffy, Eamon J
- Estcourt, Lise J
- Fitzgerald, Mark
- Goossens, Herman
- Haniffa, Rashan
- Higgins, Alisa M
- Hills, Thomas E
- Horvat, Christopher M
- Lamontagne, Francois
- Lawler, Patrick R
- Leavis, Helen L
- Linstrum, Kelsey M
- Litton, Edward
- Lorenzi, Elizabeth
- Marshall, John C
- Mayr, Florian B
- McAuley, Daniel F
- McGlothlin, Anna
- McGuinness, Shay P
- McVerry, Bryan J
- Montgomery, Stephanie K
- Morpeth, Susan C
- Murthy, Srinivas
- Orr, Katrina
- Parke, Rachael L
- Parker, Jane C
- Patanwala, Asad E
- Pettilä, Ville
- Rademaker, Emma
- Santos, Marlene S
- Saunders, Christina T
- Seymour, Christopher W
- Shankar-Hari, Manu
- Sligl, Wendy I
- Turgeon, Alexis F
- Turner, Anne M
- van de Veerdonk, Frank L
- Zarychanski, Ryan
- Green, Cameron
- Lewis, Roger J
- Angus, Derek C
- McArthur, Colin J
- Berry, Scott
- Webb, Steve A
- Derde, Lennie P G
2021
Details
- Autor(en) / Beteiligte
- Gordon, Anthony C
- Mouncey, Paul R
- Al-Beidh, Farah
- Rowan, Kathryn M
- Nichol, Alistair D
- Arabi, Yaseen M
- Annane, Djillali
- Beane, Abi
- van Bentum-Puijk, Wilma
- Berry, Lindsay R
- Bhimani, Zahra
- Bonten, Marc J M
- Bradbury, Charlotte A
- Brunkhorst, Frank M
- Buzgau, Adrian
- Cheng, Allen C
- Detry, Michelle A
- Duffy, Eamon J
- Estcourt, Lise J
- Fitzgerald, Mark
- Goossens, Herman
- Haniffa, Rashan
- Higgins, Alisa M
- Hills, Thomas E
- Horvat, Christopher M
- Lamontagne, Francois
- Lawler, Patrick R
- Leavis, Helen L
- Linstrum, Kelsey M
- Litton, Edward
- Lorenzi, Elizabeth
- Marshall, John C
- Mayr, Florian B
- McAuley, Daniel F
- McGlothlin, Anna
- McGuinness, Shay P
- McVerry, Bryan J
- Montgomery, Stephanie K
- Morpeth, Susan C
- Murthy, Srinivas
- Orr, Katrina
- Parke, Rachael L
- Parker, Jane C
- Patanwala, Asad E
- Pettilä, Ville
- Rademaker, Emma
- Santos, Marlene S
- Saunders, Christina T
- Seymour, Christopher W
- Shankar-Hari, Manu
- Sligl, Wendy I
- Turgeon, Alexis F
- Turner, Anne M
- van de Veerdonk, Frank L
- Zarychanski, Ryan
- Green, Cameron
- Lewis, Roger J
- Angus, Derek C
- McArthur, Colin J
- Berry, Scott
- Webb, Steve A
- Derde, Lennie P G
- Titel
- Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
- Ist Teil von
- The New England journal of medicine, 2021-04, Vol.384 (16), p.1491-1502
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2021
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The interleukin-6 receptor blockers tocilizumab and sarilumab were tested against standard care in a randomized trial involving patients newly admitted to the intensive care unit and requiring respiratory or blood-pressure support. The median number of organ support–free days was 10 with tocilizumab, 11 with sarilumab, and 0 with standard care.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa2100433Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7953461
- Format
- –
- Schlagworte
- Adult, Aged, Antibodies, Monoclonal, Humanized - adverse effects, Antibodies, Monoclonal, Humanized - therapeutic use, Bayesian analysis, Body weight, Consent, Coronaviruses, COVID-19, COVID-19 - complications, COVID-19 - mortality, COVID-19 - therapy, COVID-19 Drug Treatment, Critical Illness, Cytokines, Design, FDA approval, Female, Hospital Mortality, Humans, Intensive Care Units, Interleukin 6, Intervention, Life Sciences, Male, Mathematical models, Middle Aged, Odds Ratio, Original, Pandemics, Patients, Pneumonia, Receptors, Interleukin-6 - antagonists & inhibitors, Respiration, Artificial, Statistical analysis, Survival, Ventilators