Details

Autor(en) / Beteiligte

• Gao, Yimeng
• Jin, Hongzhong

Titel

Plasminogen activator inhibitor‐1: a potential etiological role in livedoid vasculopathy

Ist Teil von

• International wound journal, 2020-12, Vol.17 (6), p.1902-1908

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Livedoid vasculopathy (LV) is a chronic, recurrent skin disorder with unknown aetiology and pathogenesis that seriously affects the quality of life of people who suffer from it. Plasminogen activator inhibitor (PAI)‐1 is a primary inhibitory component of the endogenous fibrinolytic system in blood coagulation. PAI‐1 also plays a role in many other physiological processes and activities, including thrombosis, fibrosis, wound healing, angiogenesis, inflammation, cell migration, and adhesion. Enhanced expression and genotype polymorphism of PAI‐1 have been observed in LV patients. In this review, we summarise the known functions of PAI‐1 with emphasis on the roles that PAI‐1 probably plays in the pathogenesis of LV, thereby illustrating that PAI‐1 represents a potential LV biomarker and therapeutic target for treating LV.