Details

Autor(en) / Beteiligte

• Carrot-Zhang, Jian
• Soca-Chafre, Giovanny
• Patterson, Nick
• Thorner, Aaron R
• Nag, Anwesha
• Watson, Jacqueline
• Genovese, Giulio
• Rodriguez, July
• Gelbard, Maya K
• Corrales-Rodriguez, Luis
• Mitsuishi, Yoichiro
• Ha, Gavin
• Campbell, Joshua D
• Oxnard, Geoffrey R
• Arrieta, Oscar
• Cardona, Andres F
• Gusev, Alexander
• Meyerson, Matthew

Titel

Genetic ancestry contributes to somatic mutations in lung cancers from admixed latin american populations

Ist Teil von

• Cancer discovery, 2021-03, Vol.11 (3), p.591-598, Article 591

Ort / Verlag

United States

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Inherited lung cancer risk, particularly in nonsmokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden, and specific driver mutations in , and . A local Native American ancestry risk score was more strongly correlated with mutation frequency compared with global ancestry correlation, suggesting that germline genetics (rather than environmental exposure) underlie these disparities. SIGNIFICANCE: The frequency of somatic and mutations in lung cancer varies by ethnicity, but we do not understand why. Our study suggests that the variation in and mutation frequency is associated with genetic ancestry and suggests further studies to identify germline alleles that underpin this association. . .