Nature (London), 2021-02, Vol.590 (7847), p.630-634
- McMahan, Katherine
- Yu, Jingyou
- Mercado, Noe B
- Loos, Carolin
- Tostanoski, Lisa H
- Chandrashekar, Abishek
- Liu, Jinyan
- Peter, Lauren
- Atyeo, Caroline
- Zhu, Alex
- Bondzie, Esther A
- Dagotto, Gabriel
- Gebre, Makda S
- Jacob-Dolan, Catherine
- Li, Zhenfeng
- Nampanya, Felix
- Patel, Shivani
- Pessaint, Laurent
- Van Ry, Alex
- Blade, Kelvin
- Yalley-Ogunro, Jake
- Cabus, Mehtap
- Brown, Renita
- Cook, Anthony
- Teow, Elyse
- Andersen, Hanne
- Lewis, Mark G
- Lauffenburger, Douglas A
- Alter, Galit
- Barouch, Dan H
2021
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- Autor(en) / Beteiligte
- McMahan, Katherine
- Yu, Jingyou
- Mercado, Noe B
- Loos, Carolin
- Tostanoski, Lisa H
- Chandrashekar, Abishek
- Liu, Jinyan
- Peter, Lauren
- Atyeo, Caroline
- Zhu, Alex
- Bondzie, Esther A
- Dagotto, Gabriel
- Gebre, Makda S
- Jacob-Dolan, Catherine
- Li, Zhenfeng
- Nampanya, Felix
- Patel, Shivani
- Pessaint, Laurent
- Van Ry, Alex
- Blade, Kelvin
- Yalley-Ogunro, Jake
- Cabus, Mehtap
- Brown, Renita
- Cook, Anthony
- Teow, Elyse
- Andersen, Hanne
- Lewis, Mark G
- Lauffenburger, Douglas A
- Alter, Galit
- Barouch, Dan H
- Titel
- Correlates of protection against SARS-CoV-2 in rhesus macaques
- Ist Teil von
- Nature (London), 2021-02, Vol.590 (7847), p.630-634
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Recent studies have reported the protective efficacy of both natural and vaccine-induced immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8 T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/s41586-020-03041-6Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7906955
- Format
- –
- Schlagworte
- Adoptive Transfer, Analysis, Animals, Antibodies, CD8 antigen, CD8-Positive T-Lymphocytes - cytology, CD8-Positive T-Lymphocytes - immunology, Cell-mediated immunity, Chemical compounds, Coronaviruses, COVID-19 - immunology, COVID-19 - prevention & control, COVID-19 - therapy, COVID-19 - virology, Depletion, Disease Models, Animal, Experiments, Female, Humoral immunity, Immune response, Immunity, Immunization, Passive, Immunoglobulin G, Immunoglobulin G - administration & dosage, Immunoglobulin G - analysis, Immunoglobulin G - immunology, Infections, Lavage, Lymphocytes, Lymphocytes T, Macaca mulatta - immunology, Macaca mulatta - virology, Male, Methods, Pharmacology, Principal components analysis, Regression Analysis, Respiration, Respiratory diseases, SARS-CoV-2 - immunology, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Vaccination, Vaccines, Viral diseases, Viral Load - immunology