Molecular pain, 2021, Vol.17, p.1744806921990934
2021
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model
- Ist Teil von
- Molecular pain, 2021, Vol.17, p.1744806921990934
- Ort / Verlag
- Los Angeles, CA: SAGE Publications
- Erscheinungsjahr
- 2021
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chronic pain is highly prevalent worldwide and severely affects daily lives of patients and family members. Praeruptorin C (Pra-C) is a main active ingredient derived from Peucedanum praeruptorum Dunn, traditionally used as antibechic, anti-bronchitis and anti-hypertension drug. Here, we evaluated the effects of Pra-C in a chronic inflammatory pain mouse model induced by complete Freund’s adjuvant (CFA) injection. Pra-C (3 mg/kg) treatment for just 3 days after CFA challenge relieved CFA-induced mechanical allodynia and hindpaw edema in mice. In the anterior cingulate cortex (ACC), Pra-C treatment inhibited microglia activation and reduced levels of proinflammatory cytokines, TNF-α and IL-1β, and suppressed upregulation of glutamate receptors caused by CFA injection. In addition, Pra-C attenuated neuronal hyperexcitability in ACC of CFA-injected mice. In vitro studies confirmed the analgesic effect of Pra-C was due to its inhibitory ability on microglial activation. In conclusion, Pra-C administration had a certain effect on relieving chronic pain by inhibiting microglial activation, attenuating proinflammatory cytokine releasing and regulating excitatory synaptic proteins in the ACC of the CFA-injected mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1744-8069eISSN: 1744-8069DOI: 10.1177/1744806921990934Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7894694
- Format
- –
- Schlagworte
- Analgesics, Analgesics - pharmacology, Analgesics - therapeutic use, Animals, Bronchitis, Cell Line, Chronic pain, Chronic Pain - complications, Chronic Pain - drug therapy, Chronic Pain - physiopathology, Cortex (cingulate), Coumarins - chemistry, Coumarins - pharmacology, Coumarins - therapeutic use, Cytokines - metabolism, Disease Models, Animal, Edema, Edema - complications, Edema - pathology, Edema - physiopathology, Freund's Adjuvant, Glutamic acid receptors, Gyrus Cinguli - pathology, Hyperalgesia - complications, Hyperalgesia - pathology, Hyperalgesia - physiopathology, IL-1β, Inflammation, Inflammation - complications, Inflammation - drug therapy, Inflammation Mediators - metabolism, Injection, Male, Mice, Mice, Inbred C57BL, Microglia, Microglia - pathology, Neurons - drug effects, Neurons - metabolism, Neurons - pathology, Pain, Pain perception, Synapses - drug effects, Synapses - metabolism, Synaptic Transmission - drug effects, Tumor necrosis factor-α, Up-Regulation - drug effects