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BDNF, relative preference, and reward circuitry responses to emotional communication
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2009-09, Vol.150B (6), p.762-781
Gasic, G.P.
Smoller, J.W.
Perlis, R.H.
Sun, M.
Lee, S.
Kim, B.W.
Lee, M.J.
Holt, D.J.
Blood, A.J.
Makris, N.
Kennedy, D.K.
Hoge, R.D.
Calhoun, J.
Fava, M.
Gusella, J.F.
Breiter, H.C.
2009
Details
Autor(en) / Beteiligte
Gasic, G.P.
Smoller, J.W.
Perlis, R.H.
Sun, M.
Lee, S.
Kim, B.W.
Lee, M.J.
Holt, D.J.
Blood, A.J.
Makris, N.
Kennedy, D.K.
Hoge, R.D.
Calhoun, J.
Fava, M.
Gusella, J.F.
Breiter, H.C.
Titel
BDNF, relative preference, and reward circuitry responses to emotional communication
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2009-09, Vol.150B (6), p.762-781
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Brain derived neurotrophic factor (BDNF) regulates neural development and synaptic transmission. We have tested the hypothesis that functional variation in the BDNF gene (Val66Met polymorphism, rs6265) affects brain reward circuitry encoding human judgment and decision‐making regarding relative preference. We quantified relative preference among faces with emotional expressions (angry, fearful, sad, neutral, and happy) by a keypress procedure performed offline to measure effort traded for viewing time. Keypress‐based relative preferences across the ensemble of faces were mirrored significantly by fMRI signal in the orbitofrontal cortex, amygdala, and hippocampus when passively viewing these faces. For these three brain regions, there was also a statistically significant group difference by BDNF genotype in the fMRI responses to the emotional expressions. In comparison with Val/Met heterozygotes, Val/Val individuals preferentially sought exposure to positive emotions (e.g., happy faces) and had stronger regional fMRI activation to aversive stimuli (e.g., angry, fearful, and sad faces). BDNF genotype accounted for ∼30% of the variance in fMRI signal that mirrors keypress responses to these stimuli. This study demonstrates that functional allelic variation in BDNF modulates human brain circuits processing reward/aversion information and relative preference transactions. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.30944
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7891456
Format
–
Schlagworte
Adult
,
Amygdala - physiology
,
BDNF
,
Biological and medical sciences
,
Brain-Derived Neurotrophic Factor - genetics
,
Brain-Derived Neurotrophic Factor - metabolism
,
Decision Making
,
Emotions - physiology
,
Facial Expression
,
Female
,
fMRI
,
Frontal Lobe - physiology
,
Genotype
,
Hippocampus - physiology
,
Humans
,
Magnetic Resonance Imaging
,
Male
,
Medical genetics
,
Medical sciences
,
orbitofrontal cortex
,
Polymorphism, Genetic
,
relative preference
,
Reward
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