Details

Autor(en) / Beteiligte

• Bonifacius, Agnes
• Tischer-Zimmermann, Sabine
• Dragon, Anna C.
• Gussarow, Daniel
• Vogel, Alexander
• Krettek, Ulrike
• Gödecke, Nina
• Yilmaz, Mustafa
• Kraft, Anke R.M.
• Hoeper, Marius M.
• Pink, Isabell
• Schmidt, Julius J.
• Li, Yang
• Welte, Tobias
• Maecker-Kolhoff, Britta
• Martens, Jörg
• Berger, Marc Moritz
• Lobenwein, Corinna
• Stankov, Metodi V.
• Cornberg, Markus
• David, Sascha
• Behrens, Georg M.N.
• Witzke, Oliver
• Blasczyk, Rainer
• Eiz-Vesper, Britta

Titel

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

Ist Teil von

• Immunity (Cambridge, Mass.), 2021-02, Vol.54 (2), p.340-354.e6

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its relationship to antibodies, and pre-existing immunity against endemic coronaviruses (huCoV), which has been hypothesized to be protective, were investigated in 82 healthy donors (HDs), 204 recovered (RCs), and 92 active COVID-19 patients (ACs). ACs had high amounts of anti-SARS-CoV-2 nucleocapsid and spike IgG but lymphopenia and overall reduced antiviral T cell responses due to the inflammatory milieu, expression of inhibitory molecules (PD-1, Tim-3) as well as effector caspase-3, -7, and -8 activity in T cells. SARS-CoV-2-specific T cell immunity conferred by polyfunctional, mainly interferon-γ-secreting CD4+ T cells remained stable throughout convalescence, whereas humoral responses declined. Immune responses toward huCoV in RCs with mild disease and strong cellular SARS-CoV-2 T cell reactivity imply a protective role of pre-existing immunity against huCoV. [Display omitted] •high SARS-CoV-2 IgG but overall reduced T cell immunity in active COVID-19 patients•PD-1, Tim-3, and active caspases in T cells result in impaired T cell function•stable SARS-CoV-2 T cell repertoire yet declining humoral responses during recovery•potentially protective role of pre-existing anti-huCoV CD4+ and CD8+ T cell immunity COVID-19 varies from asymptomatic infection to multiorgan failure, but data on cellular immunity against SARS-CoV-2 during disease and beyond are lacking. Bonifacius et al. show a beneficial effect of preexisting immunity to endemic coronaviruses during disease and stable cellular immunity with concomitant decrease of humoral responses early during convalescence.