Details

Autor(en) / Beteiligte

• da Silveira, Willian A.
• Fazelinia, Hossein
• Rosenthal, Sara Brin
• Laiakis, Evagelia C.
• Kim, Man S.
• Meydan, Cem
• Kidane, Yared
• Rathi, Komal S.
• Smith, Scott M.
• Stear, Benjamin
• Ying, Yue
• Zhang, Yuanchao
• Foox, Jonathan
• Zanello, Susana
• Crucian, Brian
• Wang, Dong
• Nugent, Adrienne
• Costa, Helio A.
• Zwart, Sara R.
• Schrepfer, Sonja
• Elworth, R.A. Leo
• Sapoval, Nicolae
• Treangen, Todd
• MacKay, Matthew
• Gokhale, Nandan S.
• Horner, Stacy M.
• Singh, Larry N.
• Wallace, Douglas C.
• Willey, Jeffrey S.
• Schisler, Jonathan C.
• Meller, Robert
• McDonald, J. Tyson
• Fisch, Kathleen M.
• Hardiman, Gary
• Taylor, Deanne
• Mason, Christopher E.
• Costes, Sylvain V.
• Beheshti, Afshin

Titel

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

Ist Teil von

• Cell, 2020-11, Vol.183 (5), p.1185-1201.e20

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach using biomedical profiles from fifty-nine astronauts and data from NASA’s GeneLab derived from hundreds of samples flown in space to determine transcriptomic, proteomic, metabolomic, and epigenetic responses to spaceflight. Overall pathway analyses on the multi-omics datasets showed significant enrichment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions. Importantly, NASA’s Twin Study provided a platform to confirm several of our principal findings. Evidence of altered mitochondrial function and DNA damage was also found in the urine and blood metabolic data compiled from the astronaut cohort and NASA Twin Study data, indicating mitochondrial stress as a consistent phenotype of spaceflight. [Display omitted] •Multi-omics analysis and techniques with NASA’s GeneLab platform•The largest cohort of astronaut data to date utilized for analysis•Mitochondrial dysregulation driving spaceflight health risks•NASA Twin Study data validates mitochondrial dysfunction during space missions A comprehensive multi-omics analysis from 59 astronauts and hundreds of samples flown in space provides insight into fundamental biological mechanisms affected by spaceflight and highlights mitochondrial dysregulation as a central hub for space biology.