Details

Autor(en) / Beteiligte

• Nunez, Yanelli
• Boehme, Amelia K
• Weisskopf, Marc G
• Re, Diane B
• Navas-Acien, Ana
• van Donkelaar, Aaron
• Martin, Randall V
• Kioumourtzoglou, Marianthi-Anna

Titel

Fine Particle Exposure and Clinical Aggravation in Neurodegenerative Diseases in New York State

Ist Teil von

• Environmental health perspectives, 2021-02, Vol.129 (2), p.27003

Ort / Verlag

United States: National Institute of Environmental Health Sciences

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Adult-onset neurodegenerative diseases affect millions and negatively impact health care systems worldwide. Evidence suggests that air pollution may contribute to aggravation of neurodegeneration, but studies have been limited. We examined the potential association between long-term exposure to particulate matter in aerodynamic diameter [fine particulate matter ( )] and disease aggravation in Alzheimer's (AD) and Parkinson's (PD) diseases and amyotrophic lateral sclerosis (ALS), using first hospitalization as a surrogate of clinical aggravation. We used data from the New York Department of Health Statewide Planning and Research Cooperative System (SPARCS 2000-2014) to construct annual county counts of first hospitalizations with a diagnosis of AD, PD, or ALS (total, urbanicity-, sex-, and age-stratified). We used annual concentrations estimated by a prediction model at a resolution, which we aggregated to population-weighted county averages to assign exposure to cases based on county of residence. We used outcome-specific mixed quasi-Poisson models with county-specific random intercepts to estimate rate ratios (RRs) for a 1-y exposure. We allowed for nonlinear exposure-outcome relationships using penalized splines and accounted for potential confounders. We found a positive nonlinear association that plateaued above ( , 95% CI: 1.04, 1.14 for a increase from 8.1 to ). We also found a linear positive association ( , 95% CI: 1.01, 1.09 per increase), and suggestive evidence of an association with AD. We found effect modification by age for PD and ALS with a stronger positive association in patients of age but found insufficient evidence of effect modification by sex or urbanization level for any of the outcomes. Our findings suggest that annual increase in county-level concentrations may contribute to clinical aggravation of PD and ALS. Importantly, the average annual concentration in our study was , below the current American national standards, suggesting the standards may not adequately protect the aging population. https://doi.org/10.1289/EHP7425.