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Science (American Association for the Advancement of Science), 2020-11, Vol.370 (6520)
- Shrock, Ellen
- Fujimura, Eric
- Kula, Tomasz
- Timms, Richard T
- Lee, I-Hsiu
- Leng, Yumei
- Robinson, Matthew L
- Sie, Brandon M
- Li, Mamie Z
- Chen, Yuezhou
- Logue, Jennifer
- Zuiani, Adam
- McCulloch, Denise
- Lelis, Felipe J N
- Henson, Stephanie
- Monaco, Daniel R
- Travers, Meghan
- Habibi, Shaghayegh
- Clarke, William A
- Caturegli, Patrizio
- Laeyendecker, Oliver
- Piechocka-Trocha, Alicja
- Li, Jonathan Z
- Khatri, Ashok
- Chu, Helen Y
- Villani, Alexandra-Chloé
- Kays, Kyle
- Goldberg, Marcia B
- Hacohen, Nir
- Filbin, Michael R
- Yu, Xu G
- Walker, Bruce D
- Wesemann, Duane R
- Larman, H Benjamin
- Lederer, James A
- Elledge, Stephen J
2020
Details
- Autor(en) / Beteiligte
- Shrock, Ellen
- Fujimura, Eric
- Kula, Tomasz
- Timms, Richard T
- Lee, I-Hsiu
- Leng, Yumei
- Robinson, Matthew L
- Sie, Brandon M
- Li, Mamie Z
- Chen, Yuezhou
- Logue, Jennifer
- Zuiani, Adam
- McCulloch, Denise
- Lelis, Felipe J N
- Henson, Stephanie
- Monaco, Daniel R
- Travers, Meghan
- Habibi, Shaghayegh
- Clarke, William A
- Caturegli, Patrizio
- Laeyendecker, Oliver
- Piechocka-Trocha, Alicja
- Li, Jonathan Z
- Khatri, Ashok
- Chu, Helen Y
- Villani, Alexandra-Chloé
- Kays, Kyle
- Goldberg, Marcia B
- Hacohen, Nir
- Filbin, Michael R
- Yu, Xu G
- Walker, Bruce D
- Wesemann, Duane R
- Larman, H Benjamin
- Lederer, James A
- Elledge, Stephen J
- Titel
- Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
- Ist Teil von
- Science (American Association for the Advancement of Science), 2020-11, Vol.370 (6520)
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Understanding humoral responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics, therapeutics, and vaccines. Deep serological profiling of 232 coronavirus disease 2019 (COVID-19) patients and 190 pre-COVID-19 era controls using VirScan revealed more than 800 epitopes in the SARS-CoV-2 proteome, including 10 epitopes likely recognized by neutralizing antibodies. Preexisting antibodies in controls recognized SARS-CoV-2 ORF1, whereas only COVID-19 patient antibodies primarily recognized spike protein and nucleoprotein. A machine learning model trained on VirScan data predicted SARS-CoV-2 exposure history with 99% sensitivity and 98% specificity; a rapid Luminex-based diagnostic was developed from the most discriminatory SARS-CoV-2 peptides. Individuals with more severe COVID-19 exhibited stronger and broader SARS-CoV-2 responses, weaker antibody responses to prior infections, and higher incidence of cytomegalovirus and herpes simplex virus 1, possibly influenced by demographic covariates. Among hospitalized patients, males produce stronger SARS-CoV-2 antibody responses than females.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.abd4250Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7857405
- Format
- –
- Schlagworte
- Alanine, Anatomy, Antibodies, Antibodies, Neutralizing - blood, Antibodies, Neutralizing - immunology, Antibody Formation, Antibody response, Artificial Intelligence, Assaying, Coronaviridae, Coronaviruses, Correlation analysis, COVID-19, COVID-19 - blood, COVID-19 - immunology, COVID-19 Serological Testing, Cross Reactions, Cross-reactivity, Cryoelectron Microscopy, Cytomegalovirus, Demographic variables, Demographics, Depth profiling, Diagnostic systems, Epitope Mapping, Epitopes, Epitopes - chemistry, Epitopes - genetics, Epitopes - immunology, Exposure, Feedback (Response), Female, Fever, Herpes simplex, Herpes viruses, Humans, Hypotheses, Immune response (humoral), Immunoassays, Immunogenicity, Immunology, Immunotherapy, Infections, Learning algorithms, Libraries, Machine learning, Male, Microbio, Neutralizing, Online, Patients, Peptides, Protein Conformation, Proteomes, Reactivity, Respiratory diseases, Respiratory system, SARS-CoV-2 - immunology, Scanning mutagenesis, Sensitivity, Seroconversion, Serology, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus 2, Severity of Illness Index, Spike protein, Target recognition, Vaccines, Viral diseases, Viruses