Details

Autor(en) / Beteiligte

• Garcia-Vidal, Carolina
• Sanjuan, Gemma
• Moreno-García, Estela
• Puerta-Alcalde, Pedro
• Garcia-Pouton, Nicole
• Chumbita, Mariana
• Fernandez-Pittol, Mariana
• Pitart, Cristina
• Inciarte, Alexy
• Bodro, Marta
• Morata, Laura
• Ambrosioni, Juan
• Grafia, Ignacio
• Meira, Fernanda
• Macaya, Irene
• Cardozo, Celia
• Casals, Climent
• Tellez, Adrian
• Castro, Pedro
• Marco, Francesc
• García, Felipe
• Mensa, Josep
• Martínez, José Antonio
• Soriano, Alex
• Rico, Verónica
• Hernández-Meneses, Marta
• Agüero, Daiana
• Torres, Berta
• González, Ana
• de la Mora, Lorena
• Rojas, Jhon
• Linares, Laura
• Fidalgo, Berta
• Rodriguez, Natalia
• Nicolas, David
• Albiach, Laia
• Muñoz, José
• Almuedo, Alex
• Camprubí, Daniel
• Angeles Marcos, Ma
• Cilloniz, Catia
• Fernández, Sara
• Nicolas, Jose M.
• Torres, Antoni

Titel

Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study

Ist Teil von

• Clinical microbiology and infection, 2021-01, Vol.27 (1), p.83-88

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• To describe the burden, epidemiology and outcomes of co-infections and superinfections occurring in hospitalized patients with coronavirus disease 2019 (COVID-19). We performed an observational cohort study of all consecutive patients admitted for ≥48 hours to the Hospital Clinic of Barcelona for COVID-19 (28 February to 22 April 2020) who were discharged or dead. We describe demographic, epidemiologic, laboratory and microbiologic results, as well as outcome data retrieved from electronic health records. Of a total of 989 consecutive patients with COVID-19, 72 (7.2%) had 88 other microbiologically confirmed infections: 74 were bacterial, seven fungal and seven viral. Community-acquired co-infection at COVID-19 diagnosis was uncommon (31/989, 3.1%) and mainly caused by Streptococcus pneumoniae and Staphylococcus aureus. A total of 51 hospital-acquired bacterial superinfections, mostly caused by Pseudomonas aeruginosa and Escherichia coli, were diagnosed in 43 patients (4.7%), with a mean (SD) time from hospital admission to superinfection diagnosis of 10.6 (6.6) days. Overall mortality was 9.8% (97/989). Patients with community-acquired co-infections and hospital-acquired superinfections had worse outcomes. Co-infection at COVID-19 diagnosis is uncommon. Few patients developed superinfections during hospitalization. These findings are different compared to those of other viral pandemics. As it relates to hospitalized patients with COVID-19, such findings could prove essential in defining the role of empiric antimicrobial therapy or stewardship strategies.