Details

Autor(en) / Beteiligte

• Ostkamp, Patrick
• Salmen, Anke
• Pignolet, Béatrice
• Görlich, Dennis
• Andlauer, Till F M
• Schulte-Mecklenbeck, Andreas
• Gonzalez-Escamilla, Gabriel
• Bucciarelli, Florence
• Gennero, Isabelle
• Breuer, Johanna
• Antony, Gisela
• Schneider-Hohendorf, Tilman
• Mykicki, Nadine
• Bayas, Antonios
• Then Bergh, Florian
• Bittner, Stefan
• Hartung, Hans-Peter
• Friese, Manuel A
• Linker, Ralf A
• Luessi, Felix
• Lehmann-Horn, Klaus
• Mühlau, Mark
• Paul, Friedemann
• Stangel, Martin
• Tackenberg, Björn
• Tumani, Hayrettin
• Warnke, Clemens
• Weber, Frank
• Wildemann, Brigitte
• Zettl, Uwe K
• Ziemann, Ulf
• Müller-Myhsok, Bertram
• Kümpfel, Tania
• Klotz, Luisa
• Meuth, Sven G
• Zipp, Frauke
• Hemmer, Bernhard
• Hohlfeld, Reinhard
• Brassat, David
• Gold, Ralf
• Gross, Catharina C
• Lukas, Carsten
• Groppa, Sergiu
• Loser, Karin
• Wiendl, Heinz
• Schwab, Nicholas

Titel

Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2021-01, Vol.118 (1)

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies ( = 946, = 990). Additionally, effect-modification by medication and photosensitivity-associated variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-β-treated patients. In carriers of :rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.